I have seen that Microsoft Forefront Endpoint protection has pretty decent pricing, although it seems to require a separate System Configuration Manager installed that's quite pricey.
I am currently running 8 Windows 2008 servers and would love to use Endpoint protection, but I wonder if it's going to be a lot of work to accomplish this due to the requirement of System Configuration Manager.
I am not sure SCCM would help me in any other way, except for anti-virus. A four digit price tag would be a bit pricey considering that the actual Forefront licenses are reasonably priced.