Long story short, no, not really.
The closest you can probably come is to disable the warning for all drives
(add the DWORD key "NoLowDiskSpaceChecks" with a value of 1 to /Software/Microsoft/Windows/CurrentVersion/Policies/Explorer in a hive--most references on the internet say to put this in HKCU, but I'd probably try putting it in HKLM if you don't want users other than the one currently logged in to keep getting bugged.)
and then set up some analog as close as possible to the same type of warning for the drives you do want to be alerted for. (This question seems to be along the lines of what you would want, and doing things this way has the obvious advantages of a configurable threshold and the ability to set up email alerts rather than simple popups. The answer there pointing to this MS KB article in particular seems like it would replicate the functionality of the normal disk space alerts fairly closely if configured with the same values and alert types.)