We have one developer machine which crashes all applications whenever it is unlocked after being locked for a while (15-30min or more I think)
The machine will start throwing an generic XXX has encountered an error and needs to close error for every running process, including the standard services seen in task manager such as ccApp, svcHost, wuauclt, etc.
My suspicion is it is memory related since that machine only has 4GB of memory and usually multiple high-memory applications are open such as Project, Visio, Blend, Visual Studio, etc.
The machine is running XP SP3.