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Can I use persistent connection when using combination of NGINX + PHP-FPM?

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There would be nothing holding you back by doing so (though I have never done it before), but I would highly advise not to use persistent connections in MySQL. It would just give your server way more overhead than what it needs.

Take a look at the below Stack Overflow link for some more info: https://stackoverflow.com/questions/2252612/mysql-persistent-connections

If you want more performance out of your server, take a look into HTTP caching like Varnish. Varnish will have a much heavier impact on your performance than enabling persistent connections.

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