We recently switched out our Cisco 6500 core switch for a pair of Dell PowerConnect 6248 stacks. Since then, our Network Load Balanced Sharepoint, which runs on two virtual machines on an ESX cluster has been behaving very poorly. The symptoms are that opening and saving documents stored in sharepoint takes a very very long time. There are no errors showing up on the Sharepoint servers or SQL server, just a lot of annoyed users. Initially I thought there was no way NLB could cause this, but as soon as we repointed the DNS records for our intranet to the ip address of one of the web front ends, the problems disappeared.
We suspect there is an issue related to multicast in the Dell configs - NLB is configured for multicast, but not IGMP.
Has anyone got a similar set up to us and fixed this sort of issue? Sharepoint on VMware ESX, with Dell PowerConnect switches.