How to best tune a Windows PC for development purposes?

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Either don't install antivirus software or disable scan-on-access (and if not system-wide, then at least for your development directories). This can make a big difference in compile time.

See also this answer.

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Also, most antivirus scanners have the ability to filter out certain directories from real-time scanning. – Wedge May 1 '09 at 1:53
Good point, and edited in. – mmyers May 1 '09 at 1:56
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There are some utilites to change the ntfs behavior, instead of editing the registry.

fsutil behavior set disable8dot3 1

fsutil behavior set disablelastaccess 1

put a second disk in the machine, to avoid thrashing

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Set 1600x1200 or 1960x1200 or whatever is appropriate -- some very high resolution screen, but then set big fonts so you don't need a magnifying glass to read. This allows you to have multiple windows up next to each other.

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