What is the most recommended optimal my.cnf settings for the newest MacBook Pro 15" i7 with 4GB of RAM.

http://www.apple.com/macbookpro/specs.html

Only for local processing only. I want it to be full performance of speed as I use heavy data processing of MySQL locally.

Thank You.

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Use rackerhacker/MySQLTuner-perl - GitHub to give recommendations on my.cnf changes. You'll need to run sample jobs to let tuner gather specs and make recommendations, And there's also Munin for monitoring.

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