I am building a site that I anticipate will have high usage. Currently, my registrar (GoDaddy) is handling DNS. However, Amazon's Route 53 looks interesting. They promise high speed and offer globally distributed DNS servers and a programmable interface. While GoDaddy doesn't offer a programmable interface, I assume their servers are geographically distributed as well.
What are the main reasons I should opt to use Amazon Route 53 over free registrar-based DNS?