Is there a way to tell IIS to us another SMTP relay?

Something like this?

Application(s) sends email SMTP relay on server A.
Server A sends email to SMTP realy on server B.
Server B send mail to recipient.
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You can set a gateway to send all remote mails. But i don't think you can set it "by application". So all mails from all applications on server A will be send to server B. As i understand, recipient is not on server B, so Server B need to accept mails from server A that are not for Server B (relaying)

On server B, change relay restriction: Microsoft Technet

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