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I have an urgent paper to write on the best way to backup mails and database of over 500GB daily on a Lotus Domino Server (version 5.0.9) running on windows server 2003 for about 200 users. While limiting the amount of downtime.

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"Urgent paper" ? Forgot about the assignment? –  mfinni Mar 17 '11 at 19:37
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A lot of backup software vendors offer clients for Domino which do not require downtime for backups. Look into Tivoli Storage Manager and its associated Data Protection for Domino client.

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