Ran into some major issues with the recent Trend Worry Free 7. Basically it's causing my Citrix servers to crash and other odd problems. Many others appear to be having similar issues. In any case I've been investigating a replacement for our offices and have come to the conclusion of either:
Kaspersky or GFI/Sunbelt Vipre
Kaspersky is so granular and complicated. It also required a separate AV for our Citrix servers. Some weird versioning they have going on. However, it's a rock solid product and has some cool features coming down the line like disk encryption. It's a bit bloated IMO.
Vipre is extremely lightweight on all of the clients and the management interface is very easy to follow. I'm just wondering who else running XenApp is running Vipre or Kaspersky and their experience with it.