We decided to give a chance to a new opteron "Magny Cours" processor and instantly faced a problem with slow system response on Windows 2008 R2. BIOS and BMC firmwares are latest found on HP, no chipset drivers installed/needed, Adaptec RAID is used.

Anyone successfully run these type of servers?

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You're not giving us anything to work on, what are you trying to do here, how's the memory loaded out - more details please, much more. – Chopper3 Apr 16 '11 at 11:34
It's a fresh install, no applications are consuming CPU. – Alex Key Apr 16 '11 at 12:06
We're running the 12-core versions of these processors (in a BL465 G7) and haven't had any issues with them yet. Haven't done Server 2008r2 yet, but I HAVE done Windows 7 (there was a good reason) and ESX. – sysadmin1138 Apr 16 '11 at 12:23
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Have you setup the memory correctly? setting it up wrong can create just this kind of problem, also have you applied the latest Proliant Support Pack? – Chopper3 Apr 16 '11 at 12:34
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@Alex - please feel free to post your answer and mark it as accepted. – Ben Pilbrow Apr 16 '11 at 13:14
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Check the integrated NIC drivers, they can cause problems.

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