I have an odd problem where one of my users' UsrClass.dat hive does not load, which causes .NET ClickOnce applications to fail to start.

They are one of several users on a Windows 2000 terminal server, all the others have no problem. Nothing is mentioned in any logs. I can manually load the hive to the correct HKEY_USERS\..._Classes location using REGEDT32, which works around the problem, but I've no idea what could be causing this in the first place.

Any ideas what to check here, or any diagnostic tools or procedures that would help?

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Does something have a handle open to it in Process Explorer?

Are you running the User Profile Hive cleanup service?

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