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I am well aware that Multi-home DC's are not "fully supported" in a Server 2008 environment but is possible. I am in the process of configuring two multi-home DC's because I am at a point where we have no choice due to a firewall/captive portal. This was our previous post enter link description here

We decided to use two secondary NIC's on both of our DC's so that our third DC, which is at our branch office can communicate with the home DC's bypassing the firewall. Can Server 2008 be configured so that replication can occur between domain controllers through the secondary NIC while network workstations can continue as normal by using the first configured NIC? Because at this time, within Active Directory Sites, when configuring the DC's with the secondary IP on NIC #2, the servers still cannot communicate with each other.

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You're going to run into DNS problems with this setup. When you specify the second NIC in ADS&S, that won't force directory replication across that subnet. It would just confuse ADS&S. If you create a site-to-site VPN between the offices, that will enable AD communication through the firewall. –  charnley Jul 7 '11 at 4:46
    
Thank you charnley. –  Sean Jul 14 '11 at 21:31
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If you set it to replicate through SMTP, isn't there an easy way to force SMTP to go out a certain path?

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I never thought AD could replicate over SMTP, I will read up on it. Thanks for the suggestion. –  Sean Jul 8 '11 at 17:52
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