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I am moving to CentOS from Fedora, I know they have a common base but I need to know if there are any differences in directory structure or configuration files.

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Which version of Fedora are you on now? Are you planning to go to the most recent CentOS 6? – ewwhite Jul 29 '11 at 22:14
up vote 3 down vote accepted

If you are going to CentOS 6 they should be pretty close. The biggest thing I would keep in mind is to use the EPEL repository. Fedora packages a lot more recent software then CentOS does, so moving to CentOS 6 you will want to add it in to be able to install some of the needed applications:

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Same directories and configuration for example for apache? – mmonem Jul 29 '11 at 16:43
yeah ... most of the configuration files should feel quite natural. Which version of fedora are you moving from? For example Fedora15 is a lot heavier on SystemD then CentOS6. But fedora 13/14 -> CentOS 6 is not a major jump. – n8whnp Jul 29 '11 at 17:11

I would use either EPEL or RPMForge but not both. If you do use both, you will run into incompatibilities and it you try to get around them you will fubar your system.

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I would also recommend adding RPMForge as a means to acquire packages that may not be available in the standard CentOS distribution or the Fedora EPEL repository.

Also see:

I typically find everything I need in RPMForge, but will cherry-pick certain packages from EPEL when necessary.

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