I hope this is what you need, since you haven't provided enough details:
A) ALWAYS (and I really mean, ALWAYS) do a backup before you attempt such a change on prod
B) on mysql console:
ALTER TABLE fsckeduptable DISABLE KEYS;
SET FOREIGN_KEY_CHECKS=0;
.... do what you have to do ...
SET FOREIGN_KEY_CHECKS=1;
ALTER TABLE yourtablename ENABLE KEYS;
C) if (shit_happened) { restore backup; abort this; find another method }
D) if everything is ok, check table on slaves (show create table) and see if your modifications have propagated, then check prod apps using it; if (shit_happened) see #C)