Backups would have saved your bacon here, but I'm assuming that since you need a file locked in there behind some weird hardware error, you don't have them. So step one is to write a sticky note to yourself to get the rest of your environment backed up once you've finished ironing this problem out :)
As to the problem itself- it really does sound like a storage problem, however could even be the motherboard or some sort other component in the storage path. If you're running raid with redundancy (raid 5, 6, 10, or 1), you would be able to swap out a disk if it's not working. That said, when disks go bad, they tend to make a lot of noise about it and have helpful error messages, so I'm more inclined to think you're looking at a controller problem. If this is the case, replacing it or updating the firmware should fix your problem.
Before you consider any firmware updates or raid controller changes, have you opened a ticket with Dell? It's their gear, and they know it better than any of us.