1) Apache2+uWSGI+NGINX(for static)
2) NGINX + uWSGI
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If you're starting from scratch and don't have any Apache specific dependencies in place that drop it for straight NGINX
fewer points of failure and a server that has a much smaller memory footprint especially when scaling to larger number of requests -- though a bit trickier to setup in the beginning since NGINX is relatively new to the hosting scene compared to Apache and has significantly fewer examples to call upon
though again - this is if you are starting from scratch and don't need anything Apache specific