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This weekend Exchange 2010 stopped working with Outlook clients. Researching the problem I found out that the Exchange RPC Client Access Service is not starting. Looking at the event log this is what I get:

Message: Failed to register service principal name ExchangeMDB. Failed with error code The specified account does not exist (1317).

Source: MSExchangeRPC

Event ID: 1002

I already checked for ExchangeMDB and its is registered in AD pointing to the right box.

Any ideas on how to solve this problem?

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First of all, check SPN's for the CAS server: from an elevated command prompt run setspn -L [CAS Server name]. Second, try to change the Log On as account for the RPC Client Access Service to LocalSystem and try to start it – Mathias R. Jessen Dec 29 '11 at 2:40
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It seems the problem was not related to any Exchange functionality. It seems a GPO was changed for the OU containing the exchange server account and Network Servive or Local System were having problems starting the service. We have moved the server to a different OU and the problem is gone.

I will try to update on what in GPO was affecting those accounts later.

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