However, I'd like to move all of my domains onto a new drive. I can run a regex on this conf and get all of the Domains on a different drive, but I'd like to change the default Domain store point to that new drive for the future. How do I go about doing this?
Uninstall and reinstall SmarterMail. When you install, you specify the domain storage path.
If this doesn't appeal to you, open up your mailconfig.xml at C:\Program Files\SmarterTools\SmarterMail\Service.
Find the following block of configuration directives:
Set the rootMailPath to your heart's content. Don't forget to restart the service.