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I have a VPS running Plesk 10 on Apache. Intended use-case is my websites plus using Plesk's reseller feature to host client sites.

I've never used nginx, but I understand it's quite trivial to set it up as a reverse proxy in front of Apache to handle requests for static assets.

Is there any way of doing this without affecting Plesk's ability to create new vhosts?

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Check this out [How to configure Plesk to use nginx for sub-domains?][1] [1]: serverfault.com/questions/322076/… –  user113520 Mar 9 '12 at 14:20
That question refers to hard-coding paths in nginx.conf - I'm looking for a drop-in solution that will apply to any vhosts created by myself or a reseller. –  Chris Cox Mar 9 '12 at 18:12
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