The QSignoff folder uses a lot of disk space, can is be pared down without issue?
It's a folder used for Microsoft Error Reporting. Per this MSDN article:
If you don't want to do anything with the error reports you should be ok purging the files.
Here's another MS post that is a bit less wordy than the MSDN article. A snippet from the post:
These are the "Administrator queues" used by the "Microsoft Error Reporting" service (see http://msdn.microsoft.com/en-us/library/bb219076.aspx). It sounds like you're seeing a client computer that isn't shipping these files off to Microsoft (these are related to the "Error Reports" that users can opt to send when they see errors in applications) like it's supposed to.
W/o going into a long research project, my guess is that you can blow away those files w/o any consequence. I'd consider disabling the "Microsoft Error Reporting" feature via Group Policy (Computer Settings - Administrative Templates - System - Error Reporting).