An Alfresco manual contains this instruction:
Restart the subsystem.
I didn't even know it was possible to restart just a subsystem without restarting the whole Alfresco.
How to do?
As you're on Enterprise, you can stop and start subsystems through JMX
(You can also start and stop subsystems via code, if you need to do it programatically, the relevant code is in the org.alfresco.repo.management.subsystems package)