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One of my users is suddenly unable to access his e-mail from the Outlook client (Outlook 2003) on any PC, but can do so using Outlook webmail. I verified that MAPI access is enabled in Exchange (we're using 2007 SP2). I then disabled then enabled MAPI access, and removed then re-added his AD account to his Exchange account for permissions. Same problem.

I then granted myself access to his mailbox and was able to browse his mail folders from within my Outlook profile.

Worth noting, the user was messing around with TCP/IP settings on his PC (Windows 7 Pro) earlier today. He had, one at a time, disabled, then re-enabled the following IP services:

Deterministic Network Enhancer QoS Packet Scheduler IPv6 Link Layer Topology Discovery Mapper I/O Driver Link Layer Topology Discovery Responder

Note: The user can access e-mail using Outlook if Outlook is started in Safe-Mode. This is the same behavior across any PC he tries.

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Reinstall/Repair Office? –  tomjedrz May 18 '12 at 15:38
    
Also try a third party email client (like a Thunderbird) to see if your user can access the emails. Then you'll know if your office is goofy-ing up. –  George May 18 '12 at 15:42
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