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We have a relatively small organization (~15 users), and have used the ForeFront EndPoint Protection 2010 desktop client without the use of central management, like Configuration Manager.

Now that the System Center 2012 Configuration Manager and Endpoint Protection is rolled together as one installation package, do you have to stand up the Configuration Manager to use the Endpoint Protection desktop client? Or can we still use the desktop client as a standalone anti-virus solution?

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No, you don't need SCCM for FEP. –  jscott Jun 18 '12 at 16:02

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You do not need to have SCCM to use forefront. You do however need it if you're planning on doing any reporting on those installed clients (i.e. compliance, tracking, etc.).

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No you can stand them up separately but I believe if you want to know things like agent health you need SCCM.

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