It is theoretically possible but with such low data rates unlikely to be measurable. The NIC sends interrupts to one or more processors, the OS can be configured to limit the routing of these IRQs to specific cores. Thus if one core is processing all IRQs then a significant number of interrupts from one NIC will delay the processing of interrupts from another.
At a practical level quad-Ethernet cards can implement IRQ throttling, sharing and coalescing for the entire card thus reducing the impact of large data rates. However do realise these are problems for very high data rates, i.e. 10GigE networks and millions of packets per second.
There is an article on how IRQ routing aided performance for one company here: