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I have a fault regarding IIS 7.5 on Win Server 2008 R2, whenever I try to change any site bindings or start an application pool I get the error below:

Filename: \\?\C:\Windows\system32\inetsrv\config\applicationHost.config
Error: Cannot write configuration file

the application pools run as network service. None of the sites that are running have been affected however their configuration cannot be changed

UPDATED 05/10/2012

A reboot fixed this issue, however I am curious to know what caused it in the first place.

UPDATE 09/04/2013 The server is no longer in production.

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Have you checked the permissions on the applicationHost.config file? – Bernie White Oct 4 '12 at 21:47
Yes the permissions where fine, but I am still interested in any answers as to the cause. – flumeware Oct 5 '12 at 15:38
In my case, the server had run out of free space, and freeing up space fixed the problem. – Alexander Puchkov May 13 '15 at 16:27

I had the same problem - turned out we'd just run out of disk space.

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App Fabric can cause a Issue like that:

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Thanks for the info, however app fabric is not installed. Please see comments on above question, the question is no longer relevant to me. – flumeware Apr 9 '13 at 16:35

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