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I am using pressflow 6 and NewRelic seems to suggest that memcache is infact hurting performance as shown below :

DB Vs Memcache Load

My settings.php file :

# Varnish reverse proxy on localhost
$conf['reverse_proxy'] = TRUE;           
$conf['reverse_proxy_addresses'] = array('127.0.0.1'); 

# Memcached configuration
$conf['cache_inc'] = './sites/all/modules/memcache/memcache.inc';
$conf['memcache_servers'] = array(
         '127.0.0.1:11211' => 'default',
         );
### END Mercury settings written on 2011-11-01T07:12:49-04:00
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What part of that makes you think that memcache is negatively impacting performance? –  MDMarra Nov 4 '12 at 4:13
    
Disable memcache and see what happens. I have a feeling you won't like the result... –  Michael Hampton Nov 4 '12 at 4:37
    
Page rendering is taking more time in memcache then in DB... am I missing something in reading the chart above ? –  iTech Nov 4 '12 at 10:04
1  
If those numbers are right, your performance problems are not coming from Drupal, your database, or memcached. Look elsewhere. –  Michael Hampton Nov 5 '12 at 17:34
    
Can you post the output of top when the site is slow, or maybe a minute or two of dstat? –  Tom O'Connor Nov 5 '12 at 17:37
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