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I am using pressflow 6 and NewRelic seems to suggest that memcache is infact hurting performance as shown below :

DB Vs Memcache Load

My settings.php file :

# Varnish reverse proxy on localhost
$conf['reverse_proxy'] = TRUE;           
$conf['reverse_proxy_addresses'] = array(''); 

# Memcached configuration
$conf['cache_inc'] = './sites/all/modules/memcache/';
$conf['memcache_servers'] = array(
         '' => 'default',
### END Mercury settings written on 2011-11-01T07:12:49-04:00
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What part of that makes you think that memcache is negatively impacting performance? – MDMarra Nov 4 '12 at 4:13
Disable memcache and see what happens. I have a feeling you won't like the result... – Michael Hampton Nov 4 '12 at 4:37
Page rendering is taking more time in memcache then in DB... am I missing something in reading the chart above ? – iTech Nov 4 '12 at 10:04
If those numbers are right, your performance problems are not coming from Drupal, your database, or memcached. Look elsewhere. – Michael Hampton Nov 5 '12 at 17:34
Can you post the output of top when the site is slow, or maybe a minute or two of dstat? – Tom O'Connor Nov 5 '12 at 17:37

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