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I have a ESXi 5.1 Server and a 12TB Thecus n4200eco(~5.5TB in RAID6). I want to be able to run the virtual machines from the NAS instead of the server because the server has no RAID and I don't trust the drives in there.

Is this possible? Or is it a bad idea? And how do I achieve this if it is?

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If the NAS supports NFS or iSCSI then you can certainly use it as a datastore for vSphere.

Depending on which it supports and which you want to use, the setup is slightly different. Which does it support and which do you want to use?

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It appears that it supports both - is one better than the other for this use? – niallone Dec 5 '12 at 7:29
They each have their use cases. Personally I would use iSCSI. – joeqwerty Dec 6 '12 at 5:23

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