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How can I clear the cache of all settings and configurations for all of my Application Virtualization (App-V) applications?

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The App-V repair command reverts an application's virtualized filesystem back to it's original state.

The App-V Client UI provides access to the repair command:

enter image description here

Using Powershell you can achieve the same thing:

Repair-AppvClientPackage -Name 7-zip
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up vote 0 down vote accepted

You can use the sftmime command to change and configure App-V packages, and applications.

To clear all settings and configurations for all of your App-V applications, run the following command from a command prompt:

sftmime clear obj:app

By default, sftmime is located in the following folder:

C:\Program Files\Microsoft Application Virtualization Client
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