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I'd like to configure Lotus Domino to redirect outbound mail to a different downstream SMTP relay if a certain keyword is present in the subject line.

Is this possible? If so, can someone elaborate on the high-level steps involved to do this?

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For that level of routing you'd need to use something much more flexible and programmable like Haraka. You could forward everything to a Haraka server, and then the get_mx hook could decide where to route the mail based on Subject.

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