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Is it possible to install CRM 4.0 server and an Exchange server on two separate domains but still have them work together?

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CRM is a generic software category, not a product name. – Javier Aug 12 '09 at 22:31
I think it's safe to assume gwc is talking about MS CRM, since everything else mentioned is Microsoft-based. – Kara Marfia Aug 13 '09 at 11:59
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The answer is yes, but it can get very messy, very fast and you loose a lot of the integration that would otherwise be very easy to set up.

I know of a client that did this on two separate domains using federation, however it was very messy and I would not recommend doing it.

... That being said, if you are talking about two separate domains in the same forest, it may be a lot easier.

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