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I'm setting up a system that consists of:
2-4 database servers
2-4 webservers (running Node.js)

The webservers use the database servers heavily.
Aside from connecting to the private IPs of the database servers and using the same Availability Zone, how else can I increase the speed internally between these servers?

NOTE: This system might need to scale to 10X the size. I've used VPC before on a similar setup, but I'm not sure if that makes a difference in terms of internal speed.

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up vote 7 down vote accepted

VPC does not make any difference in latency.

The main thing you can consider if you need especially low latency is using placement groups. There are some limitations on which instance sizes support this, but if you use them, you are guaranteed very low-latency interconnects on the EC2 10Gbps network.

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