I just installed CF64 on a WinServer2008x64 machine. Previously a whole array of classic ASP and ASP.Net apps were functioning, after the CF install they're not.
I'm getting an http 500 on everything not coldfusion. I believe it's a mapping issue. CF seems to have dropped a wildcard handler mapping into the IIS config
Module IsapiModule Notification ExecuteRequestHandler Handler AboMapperCustom-89420 Error Code 0x800700c1
The upside (if you can call it that) is that the CF install took and seems to be functioning. It appears to have dropped in