There's scant documentation on this topic.
For example, the EBS initialization described in this page is an important first step for running a database on EC2:
http://docs.amazonwebservices.com/AWSEC2/latest/DeveloperGuide/index.html?instance-storage.html
I found this page buried in the Amazon Developer Guide. I think they call the Sysad guide "Developer Guide".
I have other questions as well, for example: How should you backup databases? Setup a standby database on another EC2 instance? Or use the EBS-S3 backup feature?