As mentioned in other answers, Monospace is good, plain text is fine. Comic Sans is silly, and embedding media is ridiculous (unless you're a graphics/media person, in which case you should have a showcase, not a CV).
Being in a position where I go through many CVs, and only for technical positions, I can honestly say that despite my logical assumptions to the contrary, presentation is always equal to content.
By which I mean, sure I scan the CV's for relevant technical or soft skills required by the initial JD, but if the presentation of even the best content is sloppy, I have to wonder at the attention to detail this applicant will bring to the job.
And the font face itself, though an important aspect, is only one aspect of presentation. IMHO, you need to look at layout, including but not limited to alignment, line and character spacing, indentation and separation.
The little bit of extra effort in taking a few hours to lay out your CV contents in an orderly, easy-to-read and most-searched-for-bits-where-they-can-be-readily-identified fashion will be well worth it in the end. You'll be surprised the doors it can open, if not into a specific field or company, but definitely into the minds and good graces of those whose function it is to remember those applicants that stand out and recommend them for future openings.