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OK, so, a quick rundown: _msdcs is essentially where all those AD-critical SRV records are kept. All your servers which need SRV records should be registering and refreshing them via dynamic DNS. You're (hopefully) not building your SRV records by hand. The netlogon service performs DDNS refresh, with a according to this a default refresh frequency of 1 ...

Those entries are for programmatic lookup of your domain controllers by processes which have and use the GUID. This provides a consistent DNS location to point to, which is useful when, for instance, the name of the domain changes. The entries there will match the objectGUID property on each of your domains, which you can check and compare via ADSI Edit ...