Unaligned Advanced Format drives with sector size of 4k will have degraded performance.
How do I make Disk Druid to partition drives correctly?
See this recent IBM developerWorks article about the topic. I'm not sure if Disk Druid supports partitioning based on sectors, meaning that it will let you specify the start of a partition based on sector number, rather then CHS, or size. If it doesn't I recommend partitioning manually, with a different tool, according to the advice in the article.
I solved the partitioning problem very easy. I dropped Disk Druid and before installing OS booted in linux rescue mode. Then I started parted and switched to unit s mode to use sectors. Then I created partitions I need so that every partition starts on mod8 sector (divisible by 8). That's all.