I've not realy worked with Windows Server since 2000 Advanced Server and I'm about to purchase a 2008 (standard) server for a project that I'm working on, are there any specific things I should be aware of?
windows backup does not allow you granular control of backing up files and directories, it makes one huge volume backup that is a .vhd file. you can restore individual files or you can mount a vhd file using vhdmount from virtual server 2005 as a directory.
usually most people are doing third party backup systems or backing up from another server.gd
Some small but significant changes in AD that came in with Server 2003 are likely going to bite you here too - I'm thinking stuff like what's described here: http://support.microsoft.com/kb/817433
The worst possible implementation of a start menu - ever.
Here is a nice story from the guy who were on the MS team responsible: http://moishelettvin.blogspot.com/2006/11/windows-shutdown-crapfest.html
Parallel SCSI is not supported in clusters with 2008