I found this (Difference between Roaming profiles, User Profile, Home Folder, and Redirected Folders?) but it doesn't really answer my question.
If I assign users a Home folder, is that essentially the same as redirecting the folders GPO gives me access to? (AppData, Desktop, Start Menu, Documents, Pictures, Music, Videos, Favorites, Contacts, Downloads, Links, Searches, Saved Games)? What is the benefit to using one system over the other, or should I be using both together and why?