Your question is rather unclear and doesn't give enough information to give an authoritative answer. I've also made your question more readable by forming it into sentences. I'll give you my initial thoughts and may change them if you provide more information.
Your requirements of "Before Gunicorn and after Nginx" is unclear - what exactly are you thinking you're going to cache between them, and now? You can cache in Nginx, or you can cache in the PHP behind Nginx, but typically not between them.
Nginx page caching is typically very effective. It's only useful where the user isn't logged in, because clearly you don't want to share personalised pages. If you search for "Nginx Page Caching" you'll find useful information. I have a tutorial about Nginx/Wordpress, you can adapt the configurations for your needs.
If you can clarify your setup, needs, and use cases I may be able to refine this answer.