I created a new instance of Windows Server Datacenter 2016 on AWS (Version: 1607 OS Build 14393.321). When I install a new application and try to click on it from the start menu it does not work.
This seems to be the exact same issue another user was having.
Please ignore the awesome paint job for the cursor. The screenshot did not include the cursor.
Here is how I would expect it to work:
Here is what I see for newly installed applications (Notice the row is not highlighted and you cannot click: