I currently have a Dell R710, which has slowly evolved into a pretty loaded up VMware host. Due to the way I have upgraded, I currently have 2x RAID5 arrays. Running ESXi 6.5, I have updated both VMFS to V6, and I split the load across the arrays - File server on one array, and Exchange Server on the other.
I have the opportunity now to wipe it and configure a large Raid6 instead, using 6x 2TB SATA 6Gb/s drives.
Better to keep them separated due to the differing workload between Exchange and a heavily used DC, or to make it one big array and just partition off the drives?