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Postfix is setup for

relayhost = spamfilter.example.com:25

I have a few php scripts running on the same server as postfix that send emails via the mail command (sendmail) to various email addresses (example@gmail.com). Is it possible to ignore the relayhost for mail originating from 127.0.0.1? I'd like the server to attempt delivery directly instead of relaying to our spam filter (spamfilter.example.com)

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It's possible to change the transport (sender_dependent_default_transport_maps) or relayhost (sender_dependent_relayhost_maps) used depending on sender envelope address. If the PHP scripts are run as different users than mail users, this is a very suitable solution.

In your PHP script you can even set envelope sender and From: address separate using 5th optional parameter to give envelope sender directly to Sendmail:

mail($to, $subject, $message, $headers,'-f envelope@example.com');

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