You can do S2D bare metal only. Storage Spaces (Direct) are unsupported inside the VMs (except Azure, but that’s another story to tell).


Generally speaking Storage Spaces aren’t supported for anything except raw disks AND virtual disk instances in Azure only, so you’re dealing with an unsupported configuration straight away... You can snapshot individual drives but there’s no guarantee you’ll get some consistent state, there’s no VSS-like concept for Storage Spaces SLABs. Snapshots aren’t ...


As long as you use Enterprise grade SSDs, ones coming with either battery or capacitor power loss protection you’ll be fine. Physical form factor and attachment type are irrelevant. https://techcommunity.microsoft.com/t5/storage-at-microsoft/don-t-do-it-consumer-grade-solid-state-drives-ssd-in-storage/ba-p/425914

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