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It is possible to add Advanced Auditing to Windows (starting in Windows Server 2008) to monitor specific Registry keys/entries so that if they are modified, touched, etc. in any way, an event will be logged. https://docs.microsoft.com/en-us/windows/security/threat-protection/auditing/audit-registry So in your case, you would want to monitor everything ...


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EOP can be used with on-premises Exchange solutions. Technically what happens is that you point your MX records at EOP, and then set up an outbound connector from EOP to your on-prem server(s). You can also use EOP for outbound filtering by using them as a “smart host”. The same principle applies to other cloud-based or on-prem anti-spam solutions.


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